Check drug target risk scores for Drug-Induced Liver Injury
Risk Score
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The number of unique drugs that target this protein. This counts each drug only once, even if it has multiple targets.
The number of unique drugs with "Most-DILI-Concern" status from FDA DILIrank that target this protein.
The proportion of drugs targeting this protein that are high-risk (Most-DILI-Concern). Range: 0-1, where higher values indicate more high-risk drugs.
Guilt-by-association score based on connected targets in the protein network. Higher scores indicate connections to other high-risk targets.
The final normalized risk score (0-1) that combines direct evidence (drug associations) and network evidence (guilt-by-association).
Targets are categorized into Low, Medium, and High risk based on their final DILI risk scores using quantiles.