Animal-model concordance

Dog and cat drug pairs

799 agent-and-indication pairs used both in companion animals with naturally occurring disease and in people, classified by whether the veterinary and human evidence point the same way.

Which species got there first, and how the evidence came out.
Classified pairs · 799 Human approval first · 477 No US human approval · 300 Veterinary evidence first · 22 concordant · 194 discordant · 48 mixed · 109 indeterminate · 448

Most pairs are human medicines adopted into veterinary practice later.

Click a row to see the evidence behind the verdict.

Drug Species Veterinary indication Verdict Veterinary Human Type Timing
Why there are this many

A pair exists where a published study tested a drug in companion animals with naturally occurring disease and that drug also exists in human medicine. The veterinary side comes from a systematic PubMed frame plus every trial in the NCI Comparative Oncology Trials Consortium, so the count measures the published veterinary trial literature, not the veterinary formulary. Marketed companion-animal drugs with little or no published trial literature — and drugs with no human counterpart at all, such as most parasiticides and vaccines — are correctly absent.

"Discordant" is used only where all the available evidence points the opposite way; "indeterminate" means the evidence on one side was not strong enough to call, and those pairs are kept in view rather than dropped. Timing says whether the drug was approved in humans before or after the veterinary evidence — most were approved first. The strata and confidence intervals are on the report page.