Study

Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

2013 · primary-comparison · peer reviewed: yes · record 24220145 · PubMed

6 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

Cross-species analyses using three independent human breast cancer datasets identified eight murine classes (of 17 total murine subtypes) that resemble specific human breast cancer subtypes.

Concordant · level C · mouse · oncology · 8 count · n 8/17

“Cross-species analyses using three independent human breast cancer datasets identified eight murine classes that resemble specific human breast cancer subtypes.”
page 1

The murine Normal-likeEx class associated with the human normal-like subtype based on gene set analysis across human datasets.

Concordant · level C · mouse · oncology

“As previously observed [31], the murine Normal-likeEx, C3TagEx, and Claudin-lowEx classes associate with the human normal-like, basal-like, and claudin-low subtypes, respectively.”
page 7

The murine Erbb2-likeEx class associated with the human HER2-enriched subtype across all three human datasets analyzed.

Concordant · level C · mouse · oncology

“The new murine class, Erbb2-like Ex, was associated with the human HER2-enriched subtype across all three human data sets; this human breast cancer subtype did not associate with any previously characterized murine class [31], indicating an increased ability for the current dataset to encompass more of the major human intrinsic subtypes.”
page 7

The murine MycEx class associated with human basal-like breast cancer based on gene set analysis.

Concordant · level C · mouse · oncology

“With this larger sample size, a link was also identified between the MycEx class and human basal-like breast cancer, which is consistent with multiple human studies linking basal-like breast cancers with cMYC amplification and expression signatures [39,44].”
page 7

The murine MycEx class associated with human luminal B tumors based on gene set analysis.

Concordant · level C · mouse · oncology

“Interestingly, a connection between the MycEx class and human luminal B tumors was also identified, highlighting Myc activation as a potentially important etiological mechanism that is shared between these two aggressive human subtypes.”
page 7

The murine NeuEx class associated with the human luminal A subtype based on gene set analysis.

Concordant · level C · mouse · oncology

“Previously defined as a 'luminal' model [31], the Neu Ex murine class associated with the human luminal A sub-type in this newest analysis; this correlation was somewhat surprising given the lack of ERa and ERa-regulated gene expression in the murine NeuEx class, but does suggest that human luminal A tumors have many ERa-independent features.”
page 7