Study

Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia

2014 · primary-comparison · peer reviewed: yes · record 24886351 · PubMed

5 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The gene expression patterns in the PFC of rodents treated with antipsychotics showed no apparent similarities with the human developing PFC, suggesting the medication effect does not explain the juvenile-like signature seen in schizophrenic PFC.

Discordant · level C · no species named · psychiatry/addiction

“The results showed no apparent similarities between the two conditions, suggesting that the juvenile-like gene expression patterns observed in the schizophrenic PFC could not be accounted for by medication effects.”
page 1

The gene expression patterns in the PFC of rodents treated with antipsychotics showed no apparent similarities with the human developing PFC, except for a comparison between olanzapine-treated rodent PFC and the human developing MFC (Additional file 5: Figure S4).

Mixed · level C · no species named · psychiatry/addiction

“We also showed that the PFC of rodents treated with antipsychotics exhibited no apparent similarities with the human developing PFC, except for a comparison between olanzapine-treated rodent PFC and the human developing MFC (Additional file 5: Figure S4).”
page 8

The similarity between the olanzapine-treated rat PFC and the human developing MFC was weakly but marginally significant after Bonferroni correction (P < 0.0125), suggesting olanzapine may induce some juvenile-like gene expression.

Mixed · level C · rat · psychiatry/addiction · 0.0125

“Similarity between the olanzapine-treated rodent PFC and the human developing MFC was weakly but marginally significant after Bonferroni correction (significance level of P < 0.0125; Additional file 5: Figure S40; see the Methods section and Additional file 1: Table S27), suggesting that olanzapine may have some effect on the induction of juvenile-like gene expression in adult PFC.”
page 8

110 genes overlapped between human developing MFC and Shn-2 KO mice MFC, indicating significant similarities in the pattern of transcriptome changes between the two groups (P = 0.0063).

Concordant · level C · mouse · psychiatry/addiction · 0.0063

“One hundred and 10 genes overlapped between human developing MFC and Shn-2 KO mice MFC, indicating significant similarities in the pattern of transcriptome changes between the two groups (P = 0.0063, Figure 4a, Additional file 1: Table S22).”
page 8

Of the 110 genes that overlapped between human developing MFC and Shn-2 KO mice MFC, 70 showed the same directional changes in expression.

Concordant · level C · mouse · psychiatry/addiction · 70 count · n 70/110

“Of those genes, 70 showed the same directional changes in expression (Figure 4b), and of these genes, 55 were downregulated (P = 2.5 × 10−5) whereas 15 were upregulated (P = 0.222).”
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