Study

A comparative encyclopedia of DNA elements in the mouse genome

2014 · primary-comparison · peer reviewed: yes · record 25409824 · PubMed

2 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

Only 22% of transcription factor footprints are conserved between mouse and human.

Mixed · level C · mouse · other · 22–50 percent

“Whereas only 22% of transcription factor footprints are conserved, nearly 50% of cross-regulatory connections between mouse transcription factors are conserved in human through the innovation of novel binding sites.”
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79.3% of chromatin-based enhancer predictions in the mouse genome have homologues in the human genome with at least 10% overlapping nucleotides.

Concordant · level C · mouse · cross-cutting toxicology · 67.1–79.6 percent

“This analysis showed that 79.3% of chromatin-based enhancer predictions, 79.6% of chromatin-based promoter predictions, 67.1% of the DHS, and 66.7% of the transcription factor binding sites in the mouse genome have homologues in the human genome with at least 10% overlapping nucleotides, while by random chance one expects 51.2%, 52.3%, 44.3% and 39.3%, respectively (Fig. 3a, Supplementary Information for details).”
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