Study

Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity

2017 · primary-comparison · peer reviewed: yes · record 28149283 · PubMed

2 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The paper found that changes in plasma CXCL12 concentrations in male rats exposed to repeated ethanol were similar to those observed in humans during abstinence.

Concordant · level A · rat · psychiatry/addiction

“studies conducted in male rats exposed to repeated ethanol revealed similar changes in plasma CXCL12 concentra- tions than those observed in humans during abstinence during abstinence and acute ethanol exposure also induced a decrease in CXCL12”
page 13

The paper found that changes in CCL11 concentrations in rats exposed to repeated ethanol and early stress were opposite to those observed in humans.

Discordant · level A · rat · psychiatry/addiction

“rats exposed to repeated ethanol and early stress (restraint) displayed changes in CCL11 concentrations, although the changes were opposite to those observed in humans.”
page 13