Study

Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis

2017 · primary-comparison · peer reviewed: yes · record 28935874 · PubMed

8 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The highest number of concordant gene modules between human (Gambia cohort) and 129S2 mice was 106, observed at day 21 post-infection, as shown in Figure 2.

Concordant · level C · mouse · infectious disease · 106 count

“The highest number of concordant gene modules was found on day 21 p.i. in mice (Figure 2, upper panel).”
page 6

The number of concordant gene modules between human and 129S2 mice exceeded the number of concordant modules between the two mouse strains (Figure 2).

Concordant · level C · mouse · infectious disease

“Note that the number of concordant modules between human and 129S2 mice exceeded the number of concordant modules between the two mouse models (Figure 2).”
page 6

The transcriptional signature in 129S2 mice more closely reflects human TB pathology compared to C57BL/6 mice.

Concordant · level C · mouse · infectious disease

“We conclude that the transcriptional signature in 129S2 mice more closely reflects human TB pathology as compared to C57BL/6.”
page 9

Discordances between human and mouse gene expression in whole blood were overwhelmingly related to adaptive immunity, primarily T cells.

Discordant · level C · mouse · infectious disease

“Genes related to innate immunity were largely concordant in human and murine transcriptomes, while discordant modules were overwhelmingly related to adaptive immunity, primarily T cells.”
page 9

Discordances between human and mouse gene expression in whole blood at day 21 p.i. were present only in the low-susceptible C57BL/6 mouse strain.

Discordant · level C · mouse · infectious disease

“At day 21 p.i. these discordances were present only in the low susceptible C57BL/6 mouse strain, which therefore continued to resemble individuals with persistent LTBI who do not progress to active disease.”
page 9

Gene expression in murine macrophages corresponded well with that in human macrophages.

Concordant · level C · mouse · infectious disease

“In contrast to WB, gene expression in murine macrophages corresponded well with that in human macrophages.”
page 9

There were no enriched discordant modules in the comparison of human and murine macrophages.

Concordant · level C · mouse · infectious disease · 0 count

“Unlike in the case of WB comparisons, there were no enriched discordant modules in this comparison.”
page 7

The expression regulation of the macrophage response to Mtb is largely conserved in mouse and man.

Concordant · level C · mouse · infectious disease

“Absence of discordant modules indicates that the expression regulation of the macrophage response to Mtb is largely conserved in mouse and man.”
page 8