Study

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

2017 · primary-comparison · peer reviewed: yes · record 28945830 · PubMed

7 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

87% of 129 therapeutic outcomes showed a significant association between drug responses in patient-derived xenografts and corresponding patients.

Concordant · level A · mouse · oncology · 87 percent · n 112/129

“A significant association was observed between drug responses in patient and corresponding PDXs in 87% (112/129) of the therapeutic outcomes (Figure 5A, Fisher's exact test; P=5.06× 10−16, supplementary Table S6, available at Annals of Oncology online).”
page 7

The sensitivity for the PDX drug screens was 96% (80/83).

Concordant · level A · mouse · oncology · 70–96 percent · n 80/83

“Our analysis revealed a sensitivity for the PDX drug screens of 96%, with a lower 95% confidence interval (CI) of 89% (which meets the acceptance criteria of 80%), and specificity of 70%, with a lower 95% CI of 54% (Table 1, top panel).”
page 7

The positive predictive value (PPV) for PDX drug screens was 85% (80/94).

Concordant · level A · mouse · oncology · 85 percent · n 80/94

“This resulted in positive and negative predictive values (PPVs and NPVs) of 85% and 91%, respectively. ... Table 1. Values and confidence intervals for parameters of analytical and clinical accuracy for PDX model drug screening ... Overall ... PPV 85% (80/94) 76%-91%”
page 7

The negative predictive value (NPV) for PDX drug screens was 91% (32/35).

Concordant · level A · mouse · oncology · 91 percent · n 32/35

“This resulted in positive and negative predictive values (PPVs and NPVs) of 85% and 91%, respectively. ... Table 1. Values and confidence intervals for parameters of analytical and clinical accuracy for PDX model drug screening ... Overall ... NPV 91% (32/35) 76%-98%”
page 7

When the first systemic therapy was received after tumor collection, the sensitivity of PDX drug screens was 97% (29/30).

Concordant · level A · mouse · oncology · 97 percent · n 29/30

“Table 1. Values and confidence intervals for parameters of analytical and clinical accuracy for PDX model drug screening ... Treatment is first therapy received after tumor collection ... Sensitivity 97% (29/30) 81%-99%”
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When the first systemic therapy was received after tumor collection, the specificity of PDX drug screens was 89% (16/18).

Concordant · level A · mouse · oncology · 89 percent · n 16/18

“Table 1. Values and confidence intervals for parameters of analytical and clinical accuracy for PDX model drug screening ... Treatment is first therapy received after tumor collection ... Specificity 89% (16/18) 64%-98%”
page 8

When treatment followed other therapies received after tumor collection, the sensitivity of PDX drug screens was 96% (51/53).

Concordant · level A · mouse · oncology · 96 percent · n 51/53

“Table 1. Values and confidence intervals for parameters of analytical and clinical accuracy for PDX model drug screening ... Treatment follows other therapies received after tumor collection ... Sensitivity 96% (51/53) 86%-99%”
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