Study

An integrated analysis of genes and functional pathways for aggression in human and rodent models

2018 · primary-comparison · peer reviewed: yes · record 29858598 · PubMed

3 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

One gene, ERBB4, was shared across all three categories of genetic evidence (human GWAS, rodent transcriptome, and high-risk genes from KO mice and OMIM) out of an unspecified total number of genes analyzed.

Concordant · level C · mouse · psychiatry/addiction · 1 count

“Analysis of overlap among the three main categories human GWAS, rodent transcriptome, and high-risk genes (i.e., KO mice and OMIM genes) revealed one gene, ERBB4, with supporting evidence from all three categories.”
page 6

The overlap between human GWAS and rodent transcriptome genes was not statistically significant, with 29 genes overlapping.

Discordant · level C · no species named · psychiatry/addiction · 29 count

“However, the overlap between GWAS and transcriptome genes (n = 29) was not statistically significant (p = 0.29).”
page 6

The pathway overlap between human GWAS and rodent transcriptome genes was not significant, with 27 pathways in common.

Discordant · level C · no species named · psychiatry/addiction · 27 count

“In contrast, the pathway overlap between the human GWAS and rodent transcriptome genes was not significant (N = 27, p = 0.20).”
page 7