Study

The dog as an animal model for bladder and urethral urothelial carcinoma: Comparative epidemiology and histology

2018 · primary-comparison · peer reviewed: yes · record 30008848 · PubMed

8 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

Mean age at UC diagnosis is comparable between people and dogs.

Concordant · level C · companion dog · oncology

“Mean age at UC diagnosis is comparable between people and dogs”
page 4

In contrast to people, where men have a 3-4x higher risk of urothelial carcinoma, female dogs have an >3 times higher risk to develop UC compared with males.

Discordant · level C · companion dog · oncology

“In contrast to people, female dogs have an >3 times higher risk to develop UC compared with males”
page 4

Surgically neutered dogs have a four times higher risk to develop urothelial carcinoma compared with entire dogs, paralleling the increased UC risk associated with surgical castration (oophorectomy) in women.

Concordant · level C · companion dog · oncology

“Surgically neutered dogs have a four times higher risk to develop UC compared with entire dogs.”
page 4

Non-papillary growth is associated with higher tumor grade, muscle invasion and poor prognosis in both people and dogs.

Concordant · level C · companion dog · oncology

“Non-papillary growth is associated with higher tumor grade, muscle invasion and poor prognosis in both people and dogs”
page 6

At first tumor diagnosis, tumor stage is typically higher in canine compared to human UC.

Discordant · level C · companion dog · oncology

“At first tumor diagnosis, tumor stage is typically higher in canine compared to human UC”
page 6

Urothelial carcinoma is the most common type of bladder cancer in both people and dogs with comparable frequencies.

Concordant · level C · companion dog · oncology

“UC is the most common type of bladder cancer in both people and dogs with comparable frequencies.”
page 6

Tumors with squamous or glandular differentiation are the second most common type of urothelial tumors in both people and dogs.

Concordant · level C · companion dog · oncology

“Tumors with squamous or glandular differentiation are the second most common type of urothelial tumors in both people and dogs.”
page 6

Other variants of urothelial carcinoma are rare in both species.

Concordant · level C · companion dog · oncology

“Other variants of UC are rare in both species”
page 6