Study

Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry

2019 · primary-comparison · peer reviewed: yes · record 31381180 · PubMed

2 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

67 orthologous phosphosites were significantly regulated across all three datasets (human, rat, and mouse).

Concordant · level C · no species named · cross-cutting toxicology · 67–78 count

“Sixty-seven orthologous phosphosites were significantly regulated across all three datasets and, of these, 78% were regulated in the same direction (Fig 1E; Appendix Table S1).”
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190 phosphosites were regulated in the same region of the protein across human, rat, and mouse datasets.

Concordant · level C · no species named · cross-cutting toxicology · 76–190 count

“Mapping potential orthologs by sequence window resulted in the identification of 190 phosphosites regulated in all three models (114 up- and 76 down-regulated phosphosites), representing 80 proteins (Table EV2).”
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