Study

Know Thy Model: Charting Molecular Homology in Stromal Reprogramming Between Canine and Human Mammary Tumors

2019 · narrative-review · peer reviewed: yes · record 31921858 · PubMed

4 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The paper found strong molecular homology in stromal reprogramming between canine and human mammary carcinomas.

Concordant · level C · companion dog · oncology

“In conclusion, these results clearly demonstrated that stromal reprogramming in canine and human mCA shares significant molecular homology.”
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Genes upregulated in the canine mammary carcinoma dataset were on average also upregulated in the human dataset.

Concordant · level C · companion dog · oncology

“Firstly, juxtaposition of our canine CAS dataset to a similar human dataset revealed that genes upregulated in the canine dataset were on average also upregulated in the human dataset, and likewise genes downregulated in the canine dataset were also downregulated in the human dataset.”
page 7

The canine-derived stromal signature was highly positively correlated with the enrichment of human-derived stromal signature of the TCGA breast cancer subset.

Concordant · level C · companion dog · oncology

“By doing so, we found the canine-derived stromal signature to be highly positively correlated with the enrichment of human-derived stromal signature of the TCGA breast cancer subset.”
page 7

Upregulated genes in canine cancer-associated stroma were highly enriched among adversely prognostic genes in humans.

Concordant · level C · companion dog · oncology

“And finally, we demonstrated that the high level of molecular homology between canine and human stromal reprogramming manifested in a prognostic value of the canine CAS signature, with upregulated genes in canine CAS highly enriched among adversely prognostic genes in humans, and upregulated genes in canine normal stroma highly enriched among favorably prognostic genes in humans.”
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