Study

Tripartite factors leading to molecular divergence between human and murine smooth muscle

2020 · primary-comparison · peer reviewed: yes · record 31945134 · PubMed

5 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

4 out of 16 proteins lacked complete human/mouse SMC conservation, showing differences in SMC expression in an organ-dependent manner.

Discordant · level C · mouse · cardiovascular · n 4/16

“Our results demonstrate that at the protein expression level, four out of 16 proteins lacked complete human/mouse SMC conservation, showing differences in SMC expression in an organ-dependent manner (ADIRF, AOC3, GZMM, and LPHN2/ ADGRL2).”
page 14

25 of 346 vascular factors did not have orthologues in mouse.

Discordant · level C · mouse · cardiovascular · n 25/346

“In total, 25 of these factors did not have orthologues in mouse annotated in Ensembl (see asterisks in Tables 1–3).”
page 10

84.6% of VSMC non-uniformly conserved proteins were absent in mouse.

Discordant · level C · mouse · cardiovascular · 19–84.6 percent

“Non-uniformly conserved VSMC proteins were much more likely to be absent in mouse than EC or VSMC/EC non-conserved molecules (84.6% for VSMC, compared with 19% for EC proteins and 42.1% for VSMC/EC proteins).”
page 10

78% of 32 human SMC proteins were either absent or divergent in mouse and rat.

Discordant · level C · mouse · cardiovascular · 78.0 percent · n /32

“When considering proteins in SMC (sub-set of 32 found in either VSMC only or VSMC/EC; Tables 2 and 3), 78% of these human proteins were either absent or divergent in mouse and rat (black bars in Fig 7).”
page 12

5 out of 54 non-uniformly conserved vascular factors were disrupted in mouse due to large scale genomic deletions.

Discordant · level C · mouse · cardiovascular · n 5/54

“In sum, 5/54 of the non-uniformly conserved vascular factors are disrupted in mouse due to large scale genomic deletions.”
page 12