Study

Bridging the Gap Between Fluid Biomarkers for Alzheimer’s Disease, Model Systems, and Patients

2020 · narrative-review · peer reviewed: yes · record 32982716 · PubMed

2 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The core Alzheimer's disease biomarkers have been found to translate well across species.

Mixed · level C · mouse · neurology

“The core AD biomarkers have been found to translate well across species, whereas biomarkers of neuroinflammation translate to a lesser extent.”
page 1

There is no absolute equivalence between biomarkers in human AD patients and those examined in preclinical models in terms of revealing key pathological hallmarks of the disease.

Discordant · level C · no species named · neurology

“Nevertheless, there is no absolute equivalence between biomarkers in human AD patients and those examined in preclinical models in terms of revealing key pathological hallmarks of the disease.”
page 1