Study

Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

2021 · primary-comparison · peer reviewed: yes · record 34558834 · PubMed

4 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

40% of the genes significantly altered in human chronic liver disease were detected in mouse models.

Concordant · level C · mouse · liver/GI · 0.4 percent

“Despite major interspecies differences, mouse models detected 40% of the genes significantly altered in human CLD.”
page 1

The highest recall for genes significantly altered in human NAFLD was 0.38 in the 12-month CCl4 mouse model.

Concordant · level C · mouse · liver/GI · 0.25–0.4

“Specifically, 38%, 40%, 25%, 34%, and 33% of all significantly up-regulated genes in NAFLD, NASH, HCV, PBC, and PSC, respectively, were also up-regulated in the 12-month CCl4 mouse model (Fig. 6B).”
page 15

The highest precision for human NAFLD was 0.33 in the Western-type diet mouse model.

Concordant · level C · mouse · liver/GI · 0.33

“Among the 12 mouse models analyzed, the WTD presented with the highest precision (0.33) for human NAFLD.”
page 15

The highest recall for the 12-month CCl4 mouse model was 0.4 for genes significantly altered in human chronic liver disease.

Concordant · level C · mouse · liver/GI · 0.4

“The highest recall (0.4) and precision (0.33) were observed for the model with 12-months damage induction by CCl4 and by a Western diet, respectively.”
page 1