Study

Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis

2022 · primary-comparison · peer reviewed: yes · record 35879783 · PubMed

2 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

17 shared regulons were identified between hTNFtg mice and human RA patients.

Concordant · level C · mouse · immunology/inflammation · 17 count

“A Regulatory network analysis in mouse and human datasets reveals 17 shared regulons.”
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Up to 25 of 107 core mouse genes were also target genes in human cells.

Concordant · level C · mouse · immunology/inflammation · 0.25 percent · n 25/107

“Interestingly, we find up to 25 of the 107 core mouse genes as target genes in human cells (Additional file 11: Table S10), highlighting the translational potential for genes like Tnfaip3 and 6, Tlr2, Lrrc15, and Bmp2.”
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