Study

Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis

2022 · primary-comparison · peer reviewed: yes · record 36253443 · PubMed

2 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

Out of 7413 common genes between mouse proteomic data and human transcriptome data, 48 genes showed the same expression trend.

Concordant · level C · mouse · neurology · 48 count · n 48/7413

“Of the 7413 genes found to be common to both datasets (Fig. 4a), 48 genes (12 upregulated and 36 downregulated DEGs) showed the same trend as the DEPs in our proteomic data (Fig. 4b).”
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Out of 73 common metabolites between mouse metabolomic data and human metabolomic/lipidomic data, 2 metabolites showed significantly increased levels in both Cntnap2 KO mice and ASD patients.

Concordant · level C · mouse · neurology · 2 count · n 2/73

“Among these overlapping metabolites, PC(38:0) and PC(O-42:2) were DEMs with levels significantly increased in both Cntnap2 KO mice and ASD patients (Fig. 4d–e, and Supplementary Table S6–8).”
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