Study
Expression profiles of the autism-related SHANK proteins in the human brain
2023 · primary-comparison · peer reviewed: yes · record 37953224 · PubMed
6 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.
The overall expression pattern of SHANK proteins was largely conserved in defined brain regions between animals and humans.
Concordant · level C · no species named · neurology
“In summary, these data show that the overall expression pattern of SHANK is largely conserved in defined brain regions; however, differences do exist, which need to be considered in the translation of rodent studies.”
page 1
SHANK2 isoform expression was largely conserved between mice and humans.
Concordant · level C · mouse · neurology
“SHANK2 and SHANK3 isoforms in brain lysates were largely conserved between mice and humans.”
page 12
SHANK2 expression in the brainstem was higher in humans compared to mice.
Discordant · level C · mouse · neurology
“however, higher SHANK2 expression was detected in the human brainstem and thalamus when compared to mice.”
page 1
SHANK2 expression in the amygdala was lower in humans compared to mice.
Discordant · level C · mouse · neurology
“One of the lowest SHANK2 levels was found in the human amygdala, a moderately expressing region in mouse.”
page 1
SHANK2 puncta density and sum intensity in the thalamus were on average three times higher in humans than in mice.
Discordant · level C · mouse · neurology · 3 ratio
“For the THA, the neuropil density and sum intensity of SHANK2 puncta compared to CB levels were on average three times higher in humans than in mice.”
page 12
SHANK2 puncta density and sum intensity in the amygdala were considerably higher in mice compared to humans.
Discordant · level C · mouse · neurology
“In contrast, puncta density and sum intensity in the AMY were considerably higher in mice compared to humans.”
page 12
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