Study

Cross-species single-cell landscapes identify the pathogenic gene characteristics of inherited retinal diseases

2024 · primary-comparison · peer reviewed: yes · record 39055259 · PubMed

5 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The correlation among most retinal cell types across species was significantly higher than that among cell types from different categories.

Concordant · level C · no species named · ophthalmology

“By comparing the single-cell transcriptome, we analyzed a total of 259,087 cells and found that the correlation among most retinal cell types across species was significantly higher than that among cell types from different categories.”
page 4

BCs demonstrated the highest degree of interspecific conservation between humans and mice.

Concordant · level C · mouse · ophthalmology

“BCs and MGs demonstrated the highest degree of interspecific conservation between humans and mice, while there are”
page 5

The IRDs GNAT2, PDEFG, and CSPG4 displayed highly consistent expression in humans and mice.

Concordant · level C · mouse · ophthalmology

“The IRDs (GNAT2, PDEFG, and CSPG4) displayed highly consistent expression in humans and mice (Supplementary Figure 5F).”
page 12

Some IRD genes, including GNAT1, MT-ND4, and PDE6A, exhibited highly dynamic expression during the differentiation of PRs in humans, whereas these patterns were less dynamic in mice.

Mixed · level C · mouse · ophthalmology

“Some IRD genes, including GNAT1, MT-ND4, and PDE6A, exhibited highly dynamic expression during the differentiation of PRs in humans, whereas these patterns were less dynamic in mice.”
page 12

The highly expressed regenerative genes including atoh7 and mdkb were observed in zebrafish rather than in mice and humans.

Discordant · level C · mouse, zebrafish · ophthalmology

“The highly expressed regenerative genes including atoh7 and mdkb were observed in zebrafish rather than in mice and humans, which indicated the unique regenerative ability of the zebrafish retina and provided a reference for developing a targeted therapy for IRDs.”
page 12