Study

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

2025 · primary-comparison · peer reviewed: yes · record 40210624 · PubMed

4 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

61 differentially abundant proteins were commonly identified in plasma between humans and mice.

Concordant · level C · mouse · oncology · 61 count

“Comparison of the plasma DAPs identified in humans and mice revealed a total of 61 commonly identified DAPs (Supplementary Fig. 5b).”
page 8

16 out of 61 common differentially abundant proteins in plasma were also identified in the tumour tissue proteome in both mice and humans.

Concordant · level C · mouse · oncology · 16 count · n 16/61

“Interestingly, 16 out of the 61 common DAPs in plasma were also identified through the analysis of the tumour tissue proteome in both mice and humans (Supplementary Fig. 5c).”
page 8

The dysregulation patterns of common differentially abundant proteins between mice and humans showed 100% correlation at day 7.

Concordant · level C · mouse · oncology · 52.6–100 percent

“A closer examination of the fold-change trends for all 61 DAPs, revealed a 100% correlation in the dysregulation patterns between mice and humans at D7, which decreased to 65.2% at D14 and 52.6% at D18 (Supplementary Fig. 5d).”
page 8

48 potential glioblastoma biomarker candidates were identified through cross-species correlation.

Concordant · level C · no species named · oncology · 48 count

“Cross-species correlation identified 48 potential GB biomarker candidates involved in actin cytoskeleton organisation, focal adhesion, platelet activation, leukocyte migration, amino acid biosynthesis, carbon metabolism, and phagosome pathways.”
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