Study

Translating metabolomic evidence gathered from an animal model to a real human scenario: the post-mortem interval issue

2025 · primary-comparison · peer reviewed: yes · record 40839180 · PubMed

3 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The standard deviation of the error in prediction (SDEP) for human samples was significantly higher than the SDECV and higher than the error estimated in prediction considering our previously published model, namely 99 minutes.

Discordant · level A · sheep/goat · cross-cutting toxicology · 99

“Notably, human AHs display a larger data scattering indic-ative of the inherent variability in these samples. The stan-dard deviation of the error in prediction (SDEP) for human samples resulted to be 300 min across the entire PMI win-dow, highlighting that translating controlled animal experi-ments into the complexities of real-world human forensic scenarios is not directly achievable, despite supposed bio-logical similarities. Of note, the SDEP resulted significantly higher than the SDECV and higher than the error estimated in prediction considering our previously published model, namely 99 min (Locci et al., 2019).”
page 4

43 metabolites were shared between human and ovine samples.

Concordant · level C · sheep/goat · cross-cutting toxicology · 43

“A total of 46 endogenous metab-olites were identified and quantified in human samples, of which 43 were shared with the animal samples.”
page 4

Taurine and Hypoxanthine concentrations showed no differences between animal and human samples.

Concordant · level C · no species named · cross-cutting toxicology

“Interestingly, no differences in Taurine and Hypoxanthine concentrations can be seen between animal and humans as shown by Fig. 6.”
page 7