Study

A multimodal cross-species comparison of pancreas development

2025 · primary-comparison · peer reviewed: yes · record 41125606 · PubMed

3 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

Transcription factors regulated by NEUROG3 were over 50% conserved between pig and human.

Concordant · level C · pig · metabolic/endocrine · 0.5 percent

“Transcription factors regulated by NEUROG3, the endocrine master regulator, are over 50% conserved between pig and human, many being validated in human stem cell models.”
page 1

Pancreatic morphogenesis (T2) and islet formation (T3) progressed much faster in mice (42%) compared to humans (82%) and pigs (65%).

Discordant · level C · mouse · metabolic/endocrine · 0.42 percent

“In contrast, pancreatic morphogenesis (T2) and islet formation (T3) progressed much faster in mice (42%), contrary to the longer duration in human (82%) and pig (65%), when both species underwent extended acinar terminal differentiation and islet remodeling23.”
page 2

Pig and human clusters had an overall stronger correlation (r = 0.6-0.7) in pancreatic cell types compared to mouse and human clusters (r = 0.45-0.54).

Concordant · level C · pig · metabolic/endocrine · 0.6 correlation

“Pig and human clusters had an overall stronger correlation (r = 0.6-0.7), whereas MPC, Beta, and EP clusters in mouse showed the lowest correlation to human clusters (r = 0.45-0.54; Fig. 2b and Supplementary Fig. 4d).”
page 3