Study

Identification of conserved canonical marker genes in human and mouse adrenal glands using Visium spatial transcriptomics

2025 · primary-comparison · peer reviewed: yes · record 41442035 · PubMed

5 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

The Spearman correlation of log2FC values between human ZR and mouse BAT across 18 signature genes was 0.8.

Concordant · level C · mouse · other · 0.8 correlation

“At the level of differential expression, Spearman correlation of log2FC values between human ZR and mouse clusters across the 18 signature genes reached ρ=0.8 for ZR(h)/BAT(m).”
page 14

The Spearman correlation of log2FC values between human ZR and mouse ZF across 18 signature genes was 0.4.

Mixed · level C · mouse · other · -0.8–0.4 correlation

“The correlations for other clusters were considerably lower (ρ=0.4 for ZF, ZG, and medulla; ρ=−0.8 for CT/WAT), yielding a specificity margin Δρ=0.4 (Fig. 7c).”
page 14

62 canonical marker genes were conserved between the zona glomerulosa of human and mouse adrenal glands.

Concordant · level C · mouse · other · 62 count

“Using the described approach, we identified 62 canonical marker genes that are conserved between the zona glomerulosa of the human and mouse adrenal glands.”
page 6

7 canonical marker genes were conserved for the ZF in human and mouse adrenal glands.

Concordant · level C · mouse · other · 7 count

“We identified only seven canonical conserved marker genes for the ZF in both human and mouse adrenal glands.”
page 8

697 canonical marker genes were conserved between the adrenal medulla of human and mouse adrenal glands.

Concordant · level C · mouse · other · 697 count

“Using the same approach, we identified 697 canonical marker genes conserved between the adrenal medulla of human and mouse adrenal glands.”
page 8