Study

Transcriptional programs diverge in aging mouse and human skeletal muscle

2026 · primary-comparison · peer reviewed: yes · record 42172440 · PubMed

3 findings kept from this study. Each is one sentence comparing an animal with a human, extracted from the full text, checked against the located page, and adjudicated against the review's definition of an animal-versus-human comparison.

Fewer than 5% of significant GO and KEGG terms were shared between mouse and human skeletal muscle in age-associated transcriptional profiles.

Discordant · level C · mouse · pain/musculoskeletal · 5 percent

“Cross-species comparison revealed substantial divergence in age-associated transcriptional profiles, with fewer than 5% of significant GO and KEGG terms shared between species.”
page 1

Hypoxia signaling showed concordant downregulation with aging in both mouse and human skeletal muscle.

Mixed · level C · mouse · pain/musculoskeletal

“Hypoxia signaling, VEGFA, and inflammatory pathways showed concordant downregulation with aging in both species; however, angiogenesis, neurogenesis, and myogenesis demonstrated opposing or non-significant trends.”
page 1

There were 1, 2, and 0 overlapping terms in gene ontology enrichment for biological processes, molecular functions, and cellular components, respectively, between mouse and human skeletal muscle.

Discordant · level C · mouse · pain/musculoskeletal · 1 count

“In gene ontology enrichment for biological processes, molecular functions, and cellular components, there were 1, 2, and 0 overlapping terms respectively.”
page 3